Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer

Title
Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer
Author(s)
도경오Eun Jung Cho[Eun Jung Cho]Bo Sun[Bo Sun]Erin M. Wilson[Erin M. Wilson]Sandra Torregrosa-Allen[Sandra Torregrosa-Allen]Bennett D. Elzey[Bennett D. Elzey]Yoon Yeo[Yoon Yeo]
Keywords
DRUG-DELIVERY; HUMAN MONOCYTES; PACLITAXEL; PERITONEAL; CISPLATIN; EXPRESSION; PHARMACOKINETICS; GROWTH; XENOGRAFTS; CD44S
Issue Date
201501
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.37, pp.312 - 319
Abstract
Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of solid carcinomas confined within the peritoneal cavity, with potential benefits in locoregional and systemic management of residual tumors. In this study, we intended to increase local retention of platinum in the peritoneal cavity over a prolonged period of time using a nanoparticle form of platinum and an in-situ crosslinkable hyaluronic acid gel. Hyaluronic acid was chosen as a carrier due to the biocompatibility and biodegradability. We confirmed a sustained release of platinum from the nanoparticles (PtNPs) and nanoparticle/gel hybrid (PtNP/gel), receptor-mediated endocytosis of PtNPs, and retention of the gel in the peritoneal cavity over 4 weeks: conditions desirable for a prolonged local delivery of platinum. However, PtNPs and PtNP/gel did not show a greater anti-tumor efficacy than CDDP solution administered at the same dose but rather caused a slight increase in tumor burdens at later time points, which suggests a potential involvement of empty carriers and degradation products the growth of residual tumors: This study alerts that although several materials considered biocompatible and safe are used as drug carriers, they may have unwanted biological effects on the residual targets once the drug is exhausted; therefore, more attention should be paid to the selection of drug carriers. (C) 2014 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33708http://dx.doi.org/10.1016/j.biomaterials.2014.10.039
ISSN
0142-9612
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의과대학 > 생리학교실 > Articles
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