Impact of Smoking on Clinical Outcomes in Female Patients with Acute Myocardial Infarction

Title
Impact of Smoking on Clinical Outcomes in Female Patients with Acute Myocardial Infarction
Author(s)
김영조정명호[정명호]정윤아[정윤아]정해창[정해창]안영근[안영근]김충진[김충진]조명찬[조명찬]
Keywords
FOLLOW-UP; MORTALITY; WOMEN; MEN; DISEASE; RISK
Issue Date
201501
Publisher
KOREAN SOC CARDIOLOGY
Citation
KOREAN CIRCULATION JOURNAL, v.45, no.1, pp.22 - 27
Abstract
Background and Objectives: Cigarette smoking has been recognized as a prominent threat to women's health. We investigated the impact of smoking on clinical outcomes in Korean female patients after acute myocardial infarction (AMI). Subjects and Methods: Out of the AMI patients who enrolled in the Korea AMI Registry, 4444 female patients were included in this study. Patients were divided into two groups-non-smoker and smoker-according to their current smoking status. We compared in-hospital mortality and major adverse cardiac events (MACE), including cardiac death, myocardial infarction, repeated percutaneous coronary intervention (PCI), or coronary artery bypass grafting during the one-year clinical follow-up period between two groups. Results: The non-smoker group had more hypertension (HTN) and diabetes mellitus. The levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol were higher in the non-smoker group. However, in-hospital mortality was significantly higher in the smoker group (1.0% vs. 2.4%, p=0.002), and cardiac death during the 12-month clinical follow-up was significantly more frequent in the smoker group (2.2% vs. 4.5%, p=0.003). Total MACEs during the 12 months were higher in the smoker group (4.9% vs. 6.8%, p=0.014). Smoking and HTN were independent predictors of MACE {odds ratio (OR): 1.742, 95% confidence interval (CI): 1.010-3.000, p=0.046; OR: 1.573, 95% CI: 1.003-2.466, p=0.049, respectively}. Conclusion: Female smokers with AMI showed significantly higher in-hospital mortality and MACE rates during the one-year clinical follow-up period.
URI
http://hdl.handle.net/YU.REPOSITORY/33705http://dx.doi.org/10.4070/kcj.2015.45.1.22
ISSN
1738-5520
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의과대학 > 내과학교실 > Articles
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