Cytotoxic 5 alpha,8 alpha-epidioxy sterols from the marine sponge Monanchora sp.

Title
Cytotoxic 5 alpha,8 alpha-epidioxy sterols from the marine sponge Monanchora sp.
Author(s)
최혁재문보라[문보라]왕위홍[왕위홍]김희영[김희영]한동엽[한동엽]양인호[양인호]원동환[원동환]김은희[김은희]이지혜[이지혜]한철경[한철경]김현지[김현지]Merrick Ekins[Merrick Ekins]남상집[남상집]강헌중[강헌중]
Keywords
POLYCYCLIC GUANIDINE ALKALOIDS; SOFT CORAL; CRAMBE-CRAMBE; METABOLITES; TERPENOIDS; ORGANISMS; TUNICATES; PULCHRA
Issue Date
201501
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.38, no.1, pp.18 - 25
Abstract
Three new sterols, 5 alpha,8 alpha-epidioxy-24-norcholesta-6,9(11),22-trien-3 beta-ol (1), 5 alpha,8 alpha-epidioxy-cholesta-6,9(11),24-trien-3 beta-ol (2), and 5 alpha,8 alpha-epidioxy-cholesta-6,23-dien-3 beta,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
URI
http://hdl.handle.net/YU.REPOSITORY/33682http://dx.doi.org/10.1007/s12272-014-0480-8
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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