MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the hemangioma animal model for differentiating infantile hemangioma from vascular malformation

Title
MRI molecular imaging using GLUT1 antibody-Fe3O4 nanoparticles in the hemangioma animal model for differentiating infantile hemangioma from vascular malformation
Author(s)
허지안손철호[손철호]박승표[박승표]최승홍[최승홍]박성혜[박성혜]김석화[김석화]Lianji Xu[Lianji Xu]김상현[김상현]최재훈[최재훈]최태현[최태현]
Keywords
CONTRAST AGENTS; DIFFUSION; PROTEIN; TISSUE; STROKE; CELLS
Issue Date
201501
Publisher
ELSEVIER SCIENCE BV
Citation
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.11, no.1, pp.127 - 135
Abstract
The purpose of this study is to evaluate the efficacy of glucose transporter protein 1 (GLUT1) antibody-conjugated iron oxide nanoparticles (Fe3O4 NPs) as magnetic resonance imaging (MRI) molecular imaging agents for differentiating infantile hemangioma from vascular malformation in the hemangioma animal model. The conjugation of Fe3O4 NPs with anti-GLUT1 antibodies leads to a significantly increased uptake of NPs by human umbilical vein endothelial cells. MRI imaging following the intravenous injection of GLUT1 antibody-Fe3O4 NPs yielded a significantly lower signal intensity than did unconjugated Fe3O4 NPs. Upon histological examination of the GLUT1 antibody-Fe3O4 NPs, Prussian blue-stained NPs were identified in CD31-positive endothelial cells of hemangioma. In contrast, when treated with unconjugated Fe3O4 NPs, Prussian blue-stained NPs were found in macrophages rather than in endothelial cells. GLUT1 antibody conjugation can effectively target the injected Fe3O4 NPs to GLUT1-positive tumor cells in infantile hemangioma. From the Clinical Editor: This study evaluates the efficacy of glucose transporter protein 1 antibody-conjugated iron oxide nanoparticles as MRI molecular imaging agents for differentiating infantile hemangioma from vascular malformation. Results demonstrate that CD-31 positive endothelial cells are targeted by this complex, which largely accumulates in macrophages resulting in significant MRI signal changes compared to using iron oxide alone. (C) 2015 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33668http://dx.doi.org/10.1016/j.nano.2014.08.003
ISSN
1549-9634
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의과대학 > 내과학교실 > Articles
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