Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition

Title
Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition
Author(s)
정태천배옥남[배옥남]노민수[노민수]천영진[천영진]
Keywords
PERMEABILITY FACTOR; FACTOR EXPRESSION; ULTRAVIOLET-B; VEGF-C; EPIDERMAL-KERATINOCYTES; ATOPIC-DERMATITIS; FACTOR-ALPHA; FACTOR GENE; CULTURED KERATINOCYTES; HACAT KERATINOCYTES
Issue Date
201501
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.23, no.1, pp.12 - 18
Abstract
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.
URI
http://hdl.handle.net/YU.REPOSITORY/33664http://dx.doi.org/10.4062/biomolther.2014.102
ISSN
1976-9148
Appears in Collections:
약학대학 > 약학부 > Articles
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