Fabrication of a Nanofibrous Mat with a Human Skin Pattern

Title
Fabrication of a Nanofibrous Mat with a Human Skin Pattern
Author(s)
고태조김정화[김정화]장진화[장진화]정영훈[정영훈]조동우[조동우]
Keywords
ARTIFICIAL SKIN; TISSUE; DESIGN; DRESSINGS; SCAFFOLD; INVITRO
Issue Date
201501
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.31, no.1, pp.424 - 431
Abstract
A number of studies on skin tissue regeneration and wound healing have been conducted. Electrospun nanofibers have numerous advantages for use in wound healing dressings. Here, we present an electrospinning method for alteration of the surface morphological properties of electrospun mats because most previous studies focused on the materials used or the introduction of bioactive healing agents. In this study, a micromachined human skin pattern mold was used as a collector in an electrospinning setup to replicate the pattern onto the surface of the electrospun mat. We demonstrated the successful fabrication of a nanofibrous mat with a human skin pattern. To verify its suitability for wound healing, a 14-day in vitro cell culture was carried out. The results indicated that the fabricated mat not only induces equivalent cell viability to the conventional electrospun mat, but also exhibits guidance of cells along the skin pattern without significant deterioration of pattern geometry.
URI
http://hdl.handle.net/YU.REPOSITORY/33662http://dx.doi.org/10.1021/la503064r
ISSN
0743-7463
Appears in Collections:
공과대학 > 기계공학부 > Articles
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