Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in Koreans

Title
Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in Koreans
Author(s)
장병익양석균[양석균]홍명희[홍명희]최현철[최현철]Wanting Zhao[Wanting Zhao]정유선[정유선]Talin Haritunians[Talin Haritunians]예병덕[예병덕]김경조[김경조]박상형[박상형]
Keywords
INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; JAPANESE PATIENTS; VARIANTS; POLYMORPHISMS; TNFSF15; GENE; ATG16L1; IL23R; EPIDEMIOLOGY
Issue Date
201501
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
INFLAMMATORY BOWEL DISEASES, v.21, no.1, pp.1 - 7
Abstract
Background: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Methods: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. Results: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 x 10(-11), odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 x 10(-9), OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 x 10(-7), OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 x 10(-8), OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 x 10(-8), OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 x 10(-7), OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans. Conclusions: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.
URI
http://hdl.handle.net/YU.REPOSITORY/33657http://dx.doi.org/10.1097/MIB.0000000000000268
ISSN
1078-0998
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE