CA9 overexpression is an independent favorable prognostic marker in intrahepatic cholangiocarcinoma

Title
CA9 overexpression is an independent favorable prognostic marker in intrahepatic cholangiocarcinoma
Author(s)
구미진
Keywords
CARBONIC-ANHYDRASE-IX; CELL LUNG-CANCER; RECTAL-CANCER; POOR SURVIVAL; EXPRESSION; CARCINOMA; VEGF; GROWTH; BIOMARKERS; EGFR
Issue Date
201501
Publisher
E-CENTURY PUBLISHING CORP
Citation
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, v.8, no.1, pp.862 - 866
Abstract
The aim of this study is to evaluate the expression of carbonic anhydrase IX (CA9) and to identify its prognostic significance in intrahepatic cholangiocarcinoma (IHCC). We performed immunohistochemistry (IHC) for CA9 in a total of 85 IHCCs. CA9 overexpression was observed in 38 of 85 (44.7%) IHCCs. CA9 overexpression was related to tumors with intraductal growth than mass forming or periductal infiltrative type. CA9 overexpression was more observed in tumors with well/moderate differentiation than poor differentiation and without lymph node metastasis. No significant correlation was observed in CA9 overexpression with tumor size, pT, stage and lymphovascular invasion. Intrahepatic cholangiocarcinomas with CA9 overexpression showed better overall survival than that without expression (P = 0.001). In multivariate analysis, lymph node metastasis (95% CI: 2.103 (1.167-3.791), P = 0.013) was an independent poor prognostic factor. IHCC with CA9 overexpression showed a 0.5-fold (95% confidence interval, 0.328-0.944) lower risk of death compared with those of no or weak expression. CA9 overexpression was related to histologic differentiation and an independent good prognostic factor.
URI
http://hdl.handle.net/YU.REPOSITORY/33654
ISSN
1936-2625
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의과대학 > 병리학교실 > Articles
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