Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease

Title
Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease
Author(s)
김경옥최재혁[최재혁]김은수[김은수]조광범[조광범]박경식[박경식]이유진[이유진]이상민[이상민]강유진[강유진]장병익
Keywords
Inflammatory bowel diseases; Age of onset; Prognosis; Crohn disease; Colitis; ulcerative
Issue Date
201501
Publisher
대한장연구학회
Citation
Intestinal research, v.13, no.1, pp.60 - 67
Abstract
Background/Aims: Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations,data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this studywas to compare clinical characteristics based on the age at diagnosis according to the Montreal Classification in Korean IBDpatients. Methods: We recruited consecutive patients with IBD at two tertiary hospitals and retrospectively reviewed theirmedical information. Patients were divided into three groups according to their age at diagnosis: youth (<17 years), young adult(17−40 years), and middle-old (>40 years). The main clinical characteristics for comparison were the achievement of a remissionstate at the last follow-up visit, cumulative rate of surgery, and cumulative use of immunomodulators and tumor necrosisfactor-α (TNFα) blockers during the follow-up period. Results: In total, 346 IBD patients were included (Crohn’s disease [CD]146 and ulcerative colitis 200; 36 youth, 202 young adult, and 113 middle-old). The middle-old group with CD was characterizedby a predominance of uncomplicated behavior (P =0.013) and a lower frequency of perianal disease (P =0.009). The middle-old group was associated more with a less aggressive disease course than the younger group, as shown by more frequentremission (P =0.004), being less likely to undergo surgery (P <0.001), and lower cumulative use of immunomodulators andTNFα blockers (P <0.001). Conclusions: Age at diagnosis according to the Montreal Classification is an important prognosticfactor for Korean IBD patients.
URI
http://hdl.handle.net/YU.REPOSITORY/33639http://dx.doi.org/10.5217/ir.2015.13.1.60
ISSN
1598-9100
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE