Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Title
Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
Author(s)
장현욱이선Yue Lu[Yue Lu]김엽손종근이승호
Keywords
NF-KAPPA-B; ARACHIDONIC-ACID RELEASE; AFFINITY IGE RECEPTOR; 5-LIPOXYGENASE INHIBITORS; CROSS-LINKING; UP-REGULATION; MOUSE SKIN; EXPRESSION; KINASE; CYCLOOXYGENASE-2
Issue Date
201401
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.22, no.1, pp.27 - 34
Abstract
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D-2 (PGD(2)) and 5-lipoxygenase (5-LO) dependent leukotriene C-4 (LTC4) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular Ca2+ influx via phospholipase C gamma 1 (PLC gamma 1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-kappa B) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum LTC4, PGD(2), and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/33622http://dx.doi.org/10.4062/biomolther.2013.092
ISSN
1976-9148
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약학대학 > 약학부 > Articles
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