3-Deoxyglucosone: A Potential Glycating Agent Accountable for Structural Alteration in H3 Histone Protein through Generation of Different AGEs

Title
3-Deoxyglucosone: A Potential Glycating Agent Accountable for Structural Alteration in H3 Histone Protein through Generation of Different AGEs
Author(s)
최인호Saheem Ahmad[Saheem Ahmad]Gulam Rabbani[Gulam Rabbani]캄바하산이은주Rizwan Hasan Khan[Rizwan Hasan Khan]Khursheed Alam[Khursheed Alam]모하메드아쉬라프아리프타슬림얀
Keywords
TRANSFORM INFRARED-SPECTROSCOPY; SIDE-CHAIN MODIFICATIONS; END-PRODUCTS; PHYSICOCHEMICAL ANALYSIS; HUMAN-IGG; METHYLGLYOXAL; GLUCOSE; ASSAY; COMPLICATIONS; ENDPRODUCTS
Issue Date
201502
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.10, no.2
Abstract
Advanced glycation end-products (AGEs) are heterogeneous group of compounds, known to be implicated in diabetic complications. One of the consequences of the Maillard reaction is attributed to the production of reactive intermediate products such as a-oxoaldehydes. 3deoxyglucosone (3-DG), an alpha-oxoaldehyde has been found to be involved in accelerating vascular damage during diabetes. In the present study, calf thymus histone H3 was treated with 3-deoxyglucosone to investigate the generation of AGEs (N-epsilon-carboxymethyllysine, pentosidine), by examining the degree of side chain modifications and formation of different intermediates and employing various physicochemical techniques. The results clearly indicate the formation of AGEs and structural changes upon glycation of H3 by 3-deoxyglucosone, which may hamper the normal functioning of H3 histone, that may compromise the veracity of chromatin structures and function in secondary complications of diabetes.
URI
http://hdl.handle.net/YU.REPOSITORY/33620http://dx.doi.org/10.1371/journal.pone.0116804
ISSN
1932-6203
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