Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms

Title
Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms
Author(s)
최동영최혁재
Keywords
NICOTINIC ACETYLCHOLINE-RECEPTORS; GAMMA-SECRETASE INHIBITOR; 13-DESMETHYL SPIROLIDE-C; ALPHA-CONOTOXIN BUIA; SPONGE RENIERA-SARAI; METHYL-D-ASPARTATE; PENICILLIUM-CITRINUM SPI080624G1F01; ADENOSINE KINASE INHIBITOR; CALCIUM-CHANNEL SUBTYPES; FOCAL CEREBRAL-ISCHEMIA
Issue Date
201502
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.38, no.2, pp.139 - 170
Abstract
Continuous increases in the incidence of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and brain stroke demand the urgent development of therapeutics. Marine organisms are well-known producers of natural products with diverse structures and pharmacological activities. Therefore, researchers have endeavored to identify marine natural products with neuroprotective effects. In this regard, this review summarizes therapeutic targets for AD, PD, and ischemic brain stroke and marine natural products with pharmacological activities on the targets according to taxonomies of marine organisms. Furthermore, several marine natural products on the clinical trials for the treatment of neurological disorders are discussed.
URI
http://hdl.handle.net/YU.REPOSITORY/33609http://dx.doi.org/10.1007/s12272-014-0503-5
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
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