Synthesis, characterization and anticancer screening of some novel piperonyl-tetrazole derivatives

Title
Synthesis, characterization and anticancer screening of some novel piperonyl-tetrazole derivatives
Author(s)
최인호Mohammad Arshad[Mohammad Arshad]Abdul Roouf Bhat[Abdul Roouf Bhat]포커렐스미리티김지은이은주Fareeda Athar[Fareeda Athar]
Keywords
PRIMARY CYTOTOXICITY EVALUATION; BREAST-CANCER; POTENTIAL ANTICONVULSANTS; SERIES; INHIBITOR; HYDRAZONE; MECHANISM; APOPTOSIS; ANALOGS; PROTEIN
Issue Date
201401
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.71, pp.229 - 236
Abstract
A series of new 1,2-substituted tetrazole derivatives were synthesized and evaluated on MCF-7 (ER positive), MDA-MB-231 and ZR-75 (ER negative) breast cancer cell lines. Out of the fourteen compounds, three compounds 10,12 and 14 showed higher inhibitory effects on MCF-7 cells. Whereas, compound 8 exhibited higher inhibition in MDA-MB-231 and ZR-75 cells at 10(-5) M concentration. Total RNA was extracted and effect of compounds on different marker genes was studied. The gene expression of CD44, BRAC and BAX were significantly affected. The compounds were screened against the HepG2 cell line, to know if they are selectively targeting specific cancers and only 1-10 percent inhibition was found at 10(-5) M concentration. (C) 2013 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33597http://dx.doi.org/10.1016/j.ejmech.2013.11.008
ISSN
0223-5234
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생명공학부 > 생명공학부 > Articles
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