Application of antibiotics as chiral selectors for capillary electrophoretic enantioseparation of pharmaceuticals: a review

Title
Application of antibiotics as chiral selectors for capillary electrophoretic enantioseparation of pharmaceuticals: a review
Author(s)
박정학수치딕시
Keywords
CONTACTLESS CONDUCTIVITY DETECTION; PARTIAL FILLING TECHNIQUE; ENANTIOMERIC SEPARATION; MACROCYCLIC ANTIBIOTICS; LIQUID-CHROMATOGRAPHY; ZONE-ELECTROPHORESIS; BASIC DRUGS; ELECTROMIGRATION TECHNIQUES; RIFAMYCIN-B; AMINO-ACIDS
Issue Date
201401
Publisher
WILEY-BLACKWELL
Citation
BIOMEDICAL CHROMATOGRAPHY, v.28, no.1, pp.10 - 26
Abstract
Recent years have witnessed several new trends in chiral separation, for example, the enantiorecognition ability of several new antibiotics has been explored using capillary electrophoresis (CE) prior to HPLC; antibiotics have been employed as chiral selectors (CSs) in a nonaqueous CE (NACE) mode; and several new detection techniques (namely, capacitively coupled contactless conductivity detection) have been used in combination with CE for quantification of enantiomers. On account of these emerging trends, this article aims to review the application of various classes of antibiotics for CE enantioseparation of pharmaceuticals. A detailed account of the basic factors affecting enantioseparation, certain limitations of antibiotics as CSs and strategies to mitigate them, and advantages of NACE while using antibiotics as CSs has also been presented. Copyright (c) 2013 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/33589http://dx.doi.org/10.1002/bmc.2950
ISSN
0269-3879
Appears in Collections:
이과대학 > 화학생화학부 > Articles
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