PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Title
PLGA-Based Nanoparticles as Cancer Drug Delivery Systems
Author(s)
주상우요네스피로즈살라리Fatemeh Sadat Tabatabaei Mirakabad[Fatemeh Sadat Tabatabaei Mirakabad]Kazem Nejati-Koshki[Kazem Nejati-Koshki]Abolfazl Akbarzadeh[Abolfazl Akbarzadeh]Mohammad Rahmati Yamchi[Mohammad Rahmati Yamchi]Mortaza Milani[Mortaza Milani]Nosratollah Zarghami[Nosratollah Zarghami]Vahideh Zeighamian[Vahideh Zeighamian]Amirbahman Rahimzadeh[Amirbahman Rahimzadeh]Somayeh Alimohammadi[Somayeh Alimohammadi]
Keywords
IN-VITRO EVALUATION; POLY(LACTIC-CO-GLYCOLIC ACID) MICROSPHERES; POLY(BUTYL CYANOACRYLATE) NANOPARTICLES; BIODEGRADABLE POLYMERIC NANOPARTICLES; MULTIDRUG-RESISTANCE GENE; TUMOR-TARGETED DELIVERY; HUMAN GROWTH-HORMONE; PARTICLE-SIZE; LOADED NANOPARTICLES; CELLULAR UPTAKE
Issue Date
201401
Publisher
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Citation
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, v.15, no.2, pp.517 - 535
Abstract
Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained-release properties, low toxicity, and biocompatibility with tissue and cells. In the present review, the structure and properties of PLGA copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy and differential scanning calorimetry. Methods of preparation and characterization, various surface modifications, encapsulation of diverse anticancer drugs, active or passive tumor targeting and different release mechanisms of PLGA nanoparticles are discussed. Increasing experience in the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer treatment, with high efficacy and few side effects.
URI
http://hdl.handle.net/YU.REPOSITORY/33584http://dx.doi.org/10.7314/APJCP.2014.15.2.517
ISSN
1513-7368
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공과대학 > 기계공학부 > Articles
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