Nontransected Ventral Onlay-augmented Urethroplasty Using Autologous Saphenous Vein Graft in a Rabbit Model of Urethral Stricture

Title
Nontransected Ventral Onlay-augmented Urethroplasty Using Autologous Saphenous Vein Graft in a Rabbit Model of Urethral Stricture
Author(s)
송필현김범수[김범수]김현태[김현태]권세윤[권세윤]전소영[전소영]최경희[최경희]박민[박민]김대환권태균[권태균]
Keywords
SMALL-INTESTINAL SUBMUCOSA; ACELLULAR MATRIX; BUCCAL MUCOSA; RECONSTRUCTION; REPLACEMENT; SKIN; BULBAR; REPAIR
Issue Date
201401
Publisher
ELSEVIER SCIENCE INC
Citation
UROLOGY, v.83, no.1, pp.225 - 231
Abstract
OBJECTIVE To evaluate the efficacy and feasibility of nontransected ventral onlay-augmented urethroplasty using an autologous saphenous vein graft in a rabbit model of urethral stricture. METHODS Ten white male rabbits weighing 3.0-3.5 kg were selected, and a long tract urethral stricture was generated by excising an 0.8-cm wide and 2-cm long portion of the distal urethra. One month after the procedure, the rabbits were randomized into a urethral stricture group (n = 5) or urethroplasty with saphenous vein graft group (n - 5). Another 5 rabbits served as a normal control group. Retrograde urethrography was performed at 2, 4, 8, and 12 weeks after surgery in all groups, and the rabbits were killed at 12 weeks postoperatively for histopathologic and immunohistochemical evaluation. RESULTS The mean operated urethral width of the normal, stricture, and vein graft group was 10.2 +/- 0.84, 4.3 +/- 0.97, and 10.04 +/- 2.35 mm at 2 weeks postoperatively, respectively (P = .008). The 4-, 8-, and 12-week postoperative urethrograms revealed results similar to those of the 2-week postoperative urethrograms. Histologic analysis showed the neourethra was epithelialized with urothelium in the vein graft group. All the rabbits survived throughout the study period without fistula formation or infection. CONCLUSION Nontransected ventral onlay-augmented urethroplasty using an autologous saphenous vein graft can be an effective and feasible procedure for the surgical management of long tract urethral stricture. UROLOGY 83: 225-231, 2014. (C) 2014 Elsevier Inc.
URI
http://hdl.handle.net/YU.REPOSITORY/33529http://dx.doi.org/10.1016/j.urology.2013.08.030
ISSN
0090-4295
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의과대학 > 비뇨기과학교실 > Articles
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