Synthesis and biological evaluation of diverse tetrahydrobenzofuran-4-ones as potent antibacterial agents

Title
Synthesis and biological evaluation of diverse tetrahydrobenzofuran-4-ones as potent antibacterial agents
Author(s)
이용록하립개아크베르이드하야둘라김성홍[김성홍]위영중
Keywords
FUNGAL N-MYRISTOYLTRANSFERASE; CYCLIC DIAZODICARBONYL COMPOUNDS; ASYMMETRIC DIPOLAR CYCLOADDITION; EFFICIENT SYNTHESIS; RHODIUM(II)-CATALYZED REACTIONS; 1,3-DICARBONYL COMPOUNDS; ANTIMICROBIAL EVALUATION; OXIDATIVE CYCLOADDITION; CONJUGATED COMPOUNDS; NATURAL-PRODUCTS
Issue Date
201502
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.22, pp.378 - 383
Abstract
Diverse 3,5,6,7-tetrahydrobenzofuran-4-one derivatives (3a-3n) were synthesized in high yields by ruthenium complex or rhodium complex catalyzed [3 + 2] cycloaddition. The antibacterial activities of these 3,5,6,7-tetrahydrobenzofuran-4-ones were evaluated against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginos a, and Enterobacter aerogenes) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). In particular, compound 3b showed the highest antibacterial activity against P. aeruginosa and S. aureus (both MICs: 2 mu g/mL). Compound 31, which has the 2H-pyrano[2,3-b]benzofuran skeleton, exhibited excellent inhibitory activity against B. cereus (MIC: 0.5 mu g/mL) as compared with ciprofloxacin (MIC: 2 mu g/mL) and ampicillin (MIC: 1 mu g/mL). (C) 2014 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33521http://dx.doi.org/10.1016/j.jiec.2014.07.035
ISSN
1226-086X
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공과대학 > 화학공학부 > Articles
자연자원대학 > 식품공학과 > Articles
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