Penicillin G as a novel chiral selector in capillary electrophoresis

Title
Penicillin G as a novel chiral selector in capillary electrophoresis
Author(s)
박정학수치딕시
Keywords
ION-PAIR SELECTORS; BASIC DRUGS; ENANTIOMERIC SEPARATION; CLINDAMYCIN PHOSPHATE; NONAQUEOUS MEDIA; RESOLUTION; ANTIBIOTICS; ACID; CE; ENANTIOSEPARATIONS
Issue Date
201401
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.1326, pp.134 - 138
Abstract
The penicillin sub-class of beta-lactam antibiotics has not been examined for its enantiodiscriminating abilities in capillary electrophoresis (CE) until date. The present work was therefore designed to evaluate penicillin G potassium salt (PenG) as an ion-pair chiral selector (CS) using CE for its several attributes, namely, high solubility in water and lower alcohols, structure allowing multiple interactions with analytes and cost-effectiveness. Systematic experiments were performed to investigate the effect of composition of background electrolyte, applied voltage and capillary temperature on chiral separation. Baseline resolutions of enantiomers of five basic chiral drugs (namely, darifenacin, citalopram, sertraline, propranolol and metoprolol) were attained using a background electrolyte composed of water:methanol (90:10, v/v) and consisting of 10.7 or 16.1 mM CS at 20 degrees C using an applied voltage of 5 kV. (C) 2013 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33509http://dx.doi.org/10.1016/j.chroma.2013.12.018
ISSN
0021-9673
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이과대학 > 화학생화학부 > Articles
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