Normal and polar-organic-phase high-performance liquid chromatographic enantioresolution of omeprazole, rabeprazole, lansoprazole and pantoprazole using monochloro-methylated cellulose-based chiral stationary phase and determination of dexrabeprazole

Title
Normal and polar-organic-phase high-performance liquid chromatographic enantioresolution of omeprazole, rabeprazole, lansoprazole and pantoprazole using monochloro-methylated cellulose-based chiral stationary phase and determination of dexrabeprazole
Author(s)
수치딕시Rituraj Dubey[Rituraj Dubey]Ravi Bhushan[Ravi Bhushan]
Keywords
GASTROESOPHAGEAL-REFLUX DISEASE; PROTON-PUMP INHIBITORS; PHARMACOKINETIC DIFFERENCES; MOBILE PHASES; ENANTIOMERS; DRUGS; ENANTIOSEPARATION; SEPARATION; DERIVATIVES; DISORDERS
Issue Date
201401
Publisher
WILEY-BLACKWELL
Citation
BIOMEDICAL CHROMATOGRAPHY, v.28, no.1, pp.112 - 119
Abstract
Enantioresolution of four anti-ulcer drugs (chiral sulfoxides), namely, omeprazole, rabeprazole, lansoprazole and pantoprazole, was carried out by high-performance liquid chromatography using a polysaccharide-based chiral stationary phase consisting of monochloromethylated cellulose (Lux cellulose-2) under normal and polar-organic-phase conditions with ultraviolet detection at 285nm. The method was validated for linearity, accuracy, precision, robustness and limit of detection. The optimized enantioresolution method was compared for both the elution modes. The optimized method was further utilized to check the enantiomeric purity of dexrabeprazole. Copyright (c) 2013 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/33504http://dx.doi.org/10.1002/bmc.2915
ISSN
0269-3879
Appears in Collections:
중앙도서관 > rims journal
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