Midkine exacerbates pressure overload-induced cardiac remodeling

Title
Midkine exacerbates pressure overload-induced cardiac remodeling
Author(s)
Shunsuke Netsu[Shunsuke Netsu]Tetsuro Shishido[Tetsuro Shishido]Tatsuro Kitahara[Tatsuro Kitahara]Yuki Honda[Yuki Honda]Akira Funayama[Akira Funayama]Taro Narumi[Taro Narumi]Shinpei Kadowaki[Shinpei Kadowaki]Hiroki Takahashi[Hiroki Takahashi]Takuya Miyamoto[Takuya Miyamoto]Takanori Arimoto[Takanori Arimoto]Satoshi Nishiyama[Satoshi Nishiyama]Tetsu Watanabe[Tetsu Watanabe]우창훈Yasuchika Takeishi[Yasuchika Takeishi]Isao Kubota[Isao Kubota]
Keywords
CHRONIC HEART-FAILURE; MYOCARDIAL-INFARCTION; HYPERTROPHY; DYSFUNCTION; PREVENTS; MICE; INFLAMMATION; INJURY; PLEIOTROPHIN; ASSOCIATION
Issue Date
201401
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.443, no.1, pp.205 - 210
Abstract
Midkine is a multifunctional growth factor, and its serum levels are increased with the functional severity of heart failure. This study aimed to examine the role of midkine in heart failure pathogenesis. Midkine expression levels were increased in the kidney and lung after transverse aortic constriction (TAC) surgery, but not sufficiently increased in the heart. After TAC, phosphorylation of extracellular signal-regulated kinase1/2 and AKT, and the expression levels of foetal genes in the heart were considerably increased in transgenic mice with cardiac-specific overexpression of midkine (MK-Tg) compared with wild-type (WT) mice. MK-Tg mice showed more severe cardiac hypertrophy and dysfunction, and showed lower survival rate after TAC than WT mice. We conclude that midkine plays a critical role in cardiac hypertrophy and remodelling. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33497http://dx.doi.org/10.1016/j.bbrc.2013.11.083
ISSN
0006-291X
Appears in Collections:
의과대학 > 약리학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE