Concomitant Impact of High-Sensitivity C-Reactive Protein and Renal Dysfunction in Patients with Acute Myocardial Infarction

Title
Concomitant Impact of High-Sensitivity C-Reactive Protein and Renal Dysfunction in Patients with Acute Myocardial Infarction
Author(s)
김영조강용운[강용운]김민지[김민지]최준석[최준석]김창성[김창성]배은희[배은희]마성권[마성권]안용근[안용근]정명호[정명호]김수완[김수완]
Keywords
CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE; CARDIOVASCULAR EVENTS; EVALUATING ROSUVASTATIN; JUPITER JUSTIFICATION; INTERVENTION TRIAL; MORTALITY RISK; INFLAMMATION; ATHEROSCLEROSIS
Issue Date
201401
Publisher
YONSEI UNIV COLL MEDICINE
Citation
YONSEI MEDICAL JOURNAL, v.55, no.1, pp.132 - 140
Abstract
Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR >= 60 mL.min(-1).1.73 m(-2)) with low hs-CRP (<= 2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). hi a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.
URI
http://hdl.handle.net/YU.REPOSITORY/33490http://dx.doi.org/10.3349/ymj.2014.55.1.132
ISSN
0513-5796
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의과대학 > 내과학교실 > Articles
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