Microfluidic electrical sorting of particles based on shape in a spiral microchannel

Title
Microfluidic electrical sorting of particles based on shape in a spiral microchannel
Author(s)
주상우John DuBose[John DuBose]Xinyu Lu[Xinyu Lu]Saurin Patel[Saurin Patel]Shizhi Qian[Shizhi Qian]Xiangchun Xuan[Xiangchun Xuan]
Keywords
FIELD-FLOW FRACTIONATION; CELL-SEPARATION; ELECTRODELESS DIELECTROPHORESIS; DEVICES; CLASSIFICATION; MICROORGANISMS; BIOPARTICLES; BACTERIA; SYSTEMS; FORCE
Issue Date
201401
Publisher
AMER INST PHYSICS
Citation
BIOMICROFLUIDICS, v.8, no.1
Abstract
Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation. (C) 2014 AIP Publishing LLC.
URI
http://hdl.handle.net/YU.REPOSITORY/33468http://dx.doi.org/10.1063/1.4862355
ISSN
1932-1058
Appears in Collections:
공과대학 > 기계공학부 > Articles
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