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dc.contributor.author이승우ko
dc.contributor.author김현철[김현철]ko
dc.contributor.author김은주[김은주]ko
dc.contributor.author정상원[정상원]ko
dc.contributor.author이세근[이세근]ko
dc.contributor.author이성근[이성근]ko
dc.date.accessioned2015-12-17T05:04:11Z-
dc.date.available2015-12-17T05:04:11Z-
dc.date.created2015-11-13-
dc.date.issued201502-
dc.identifier.citationMACROMOLECULAR RESEARCH, v.23, no.2, pp.196 - 204-
dc.identifier.issn1598-5032-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/33462-
dc.identifier.urihttp://dx.doi.org/10.1007/s13233-015-3030-4-
dc.description.abstractGemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG)(2)-Cyt-(PBC)(2)) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteine-poly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG)(2)-Cyt-(PBC)(2) formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG)(2)-Cyt-(PBC)(2) micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.-
dc.language영어-
dc.publisherPOLYMER SOC KOREA-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectINTRACELLULAR RELEASE-
dc.subjectDIBLOCK COPOLYMERS-
dc.subjectDELIVERY SYSTEMS-
dc.subjectIN-VITRO-
dc.subjectNANOPARTICLES-
dc.subjectSURFACTANTS-
dc.subjectVESICLES-
dc.subjectDESIGN-
dc.subjectSPACER-
dc.titleGlutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers-
dc.typeArticle-
dc.identifier.wosid000350362900012-
dc.identifier.scopusid2-s2.0-84925488116-
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