Glutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers

Title
Glutathione-Responsive Gemini Polymeric Micelles as Controlled Drug Carriers
Author(s)
이승우김현철[김현철]김은주[김은주]정상원[정상원]이세근[이세근]이성근[이성근]
Keywords
BLOCK-COPOLYMER MICELLES; INTRACELLULAR RELEASE; DIBLOCK COPOLYMERS; DELIVERY SYSTEMS; IN-VITRO; NANOPARTICLES; SURFACTANTS; VESICLES; DESIGN; SPACER
Issue Date
201502
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v.23, no.2, pp.196 - 204
Abstract
Gemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG)(2)-Cyt-(PBC)(2)) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteine-poly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG)(2)-Cyt-(PBC)(2) formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG)(2)-Cyt-(PBC)(2) micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.
URI
http://hdl.handle.net/YU.REPOSITORY/33462http://dx.doi.org/10.1007/s13233-015-3030-4
ISSN
1598-5032
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공과대학 > 화학공학부 > Articles
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