Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study

Title
Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study
Author(s)
이형우이미영[이미영]최동섭[최동섭]이문규[이문규]박태선[박태선]김두만[김두만]정춘희[정춘희]김덕규[김덕규]김인주[김인주]장학철[장학철]
Keywords
IMPAIRED GLUCOSE-TOLERANCE; GLYCEMIC CONTROL; POSTPRANDIAL HYPERGLYCEMIA; CARDIOVASCULAR BENEFITS; 24-WEEK MONOTHERAPY; CONTROLLED-TRIAL; NIDDM PATIENTS; WEIGHT-GAIN; GLARGINE; EFFICACY
Issue Date
201401
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.1, pp.90 - 97
Abstract
We studied the efficacy and safety of acarbose in comparison with voglibose in type 2 diabetes patients whose blood glucose levels were inadequately controlled with basal insulin alone or in combination with metformin (or a sulfonylurea). This study was a 24-week prospective, open-label, randomized, active-controlled multi-center study. Participants were randomized to receive either acarbose (n= 59, 300 mg/day) or voglibose (n = 62, 0.9 mg/day). The mean HbA(1c) at week 24 was significantly decreased approximately 0.7% from baseline in both acarbose (from 8.43% +/- 0.71% to 7.71% +/- 0.93%) and voglibose groups (from 8.38% +/- 0.73% to 7.68% +/- 0.94%). The mean fasting plasma glucose level and self-monitoring of blood glucose data from 1 hr before and after each meal were significantly decreased at week 24 in comparison to baseline in both groups. The levels 1 hr after dinner at week 24 were significantly decreased in the acarbose group (from 233.54 +/- 69.38 to 176.80 +/- 46.63 mg/dL) compared with the voglibose group (from 224.18 +/- 70.07 to 193.01 +/- 55.39 mg/dL). In conclusion, both acarbose and voglibose are efficacious and safe in patients with type 2 diabetes who are inadequately controlled with basal insulin.
URI
http://hdl.handle.net/YU.REPOSITORY/33461http://dx.doi.org/10.3346/jkms.2014.29.1.90
ISSN
1011-8934
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의과대학 > 내과학교실 > Articles
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