Synthesis, Anticancer and Antioxidant Activity of Novel Carbazole-based Thiazole Derivatives

Title
Synthesis, Anticancer and Antioxidant Activity of Novel Carbazole-based Thiazole Derivatives
Author(s)
김정애Minh An Tran Nguyen[Minh An Tran Nguyen]Anil Kumar Mungara[Anil Kumar Mungara]김갑득[김갑득]박순흠[박순흠]
Keywords
2,4-DISUBSTITUTED THIAZOLES; ANTIPROLIFERATIVE ACTIVITY; ALPHA-AMINOPHOSPHONATES; INHIBITORS; POTENT; AGENTS; ANTIBACTERIAL; ANALOGS; DESIGN; SERIES
Issue Date
201502
Publisher
TAYLOR & FRANCIS LTD
Citation
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, v.190, no.2, pp.191 - 199
Abstract
A series of carbazole-based thiazole derivatives were synthesized and characterized. The title compounds were evaluated for their cytotoxicity against three cancer cell lines A549, MCF-7, and HT29 by MTT assay. Among several thiazole derivatives, compounds 4-(4-bromophenyl)-2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)thiazole (3f) and 2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)-4-(4-nitrophenyl)thiazole (3g) are found to display significant cytotoxicity against three cancer cell lines. These compounds have also been tested for antioxidant activity and are found to exhibit higher antioxidant activity than that of the standard BHT.
URI
http://hdl.handle.net/YU.REPOSITORY/33451http://dx.doi.org/10.1080/10426507.2014.914933
ISSN
1042-6507
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약학대학 > 약학부 > Articles
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