Structural insight into CIDE domains: the Janus face of CIDEs

Title
Structural insight into CIDE domains: the Janus face of CIDEs
Author(s)
박현호
Keywords
DNA FRAGMENTATION SYSTEM; CASPASE-ACTIVATED DNASE; FUNCTIONAL DIFFERENCES; N DOMAIN; APOPTOSIS; COMPLEX; PROTEIN; NUCLEASE; OBESITY; DFF40
Issue Date
201502
Publisher
SPRINGER
Citation
APOPTOSIS, v.20, no.2, pp.240 - 249
Abstract
Cell-death inducing DFF45-like effect domain (CIDE domain) is a protein interaction module that was initially found in DNA fragmentation factor (DFF) proteins DFF40 and DFF45. Several other CIDE-containing proteins, CIDE-A, CIDE-B, and CIDE-3, have since been identified in humans. Although the main function of these proteins is associated with apoptosis, recent studies have identified roles of CIDE-containing proteins in energy metabolism, especially involvement in control of the size of lipid droplets. Because CIDE-containing proteins perform critical tasks in apoptosis and energy metabolism and have been linked to many human diseases including cancer and obesity, studies of CIDE domains and CIDE-containing proteins are of great biological importance. This review summarizes the structural insight into CIDE and the CIDE-CIDE complex and speculates on a generalized strategy for the CIDE-CIDE interaction based on the available CIDE structures and molecular modelling.
URI
http://hdl.handle.net/YU.REPOSITORY/33436http://dx.doi.org/10.1007/s10495-014-1067-z
ISSN
1360-8185
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이과대학 > 화학생화학부 > Articles
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