Saponins, Especially Platyconic Acid A, from Platycodon grandiflorum Reduce Airway Inflammation in Ovalbumin-Induced Mice and PMA-Exposed A549 Cells

Title
Saponins, Especially Platyconic Acid A, from Platycodon grandiflorum Reduce Airway Inflammation in Ovalbumin-Induced Mice and PMA-Exposed A549 Cells
Author(s)
정태천최재호[최재호]진순우[진순우]김형균[김형균]최철영[최철영]이현선[이현선]류시용[류시용]정영철[정영철]황영중[황영중]엄연지정혜광[정혜광]
Keywords
ALLERGIC-ASTHMA; INDUCED HEPATOTOXICITY; EPITHELIAL-CELLS; MURINE MODEL; MAST-CELLS; ROOTS; INHIBITION; EXPRESSION; HYPERSECRETION; SUPPRESSION
Issue Date
201502
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.63, no.5, pp.1468 - 1476
Abstract
We investigated the inhibitory effects of Platycodon grandiflorum root-derived saponins (Changkil saponins: CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number, IgE, Th1/Th2 cytokines, and MCP-1 chemokine secretion in bronchoalveolar lavage fluid. Also, ovalbumin-increased MUC5AC, MMP-2/9, and TIMP-1/-2 mRNA expression, NF-kappa B activation, leukocytes recruitment, and mucus secretion were inhibited by CKS treatment. Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 +/- 0.2 to 1.1 +/- 0.1) by inhibiting NF-kappa B activation (from 2.3 +/- 0.2 to 1.2 +/- 0.1) via Akt (from 3.7 +/- 0.3 to 2.1 +/- 0.2) (p < 0.01) in A549 cells. Therefore, we demonstrate that CKS or PA suppressed the development of respiratory inflammation, hyperresponsiveness, and remodeling by reducing allergic responses, and they may be potential herbal drugs for allergen-induced respiratory disease prevention.
URI
http://hdl.handle.net/YU.REPOSITORY/33434http://dx.doi.org/10.1021/jf5043954
ISSN
0021-8561
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약학대학 > 약학부 > Articles
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