Safety and efficacy of fibrate-statin combination therapy compared to fibrate monotherapy in patients with dyslipidemia: A meta-analysis

Title
Safety and efficacy of fibrate-statin combination therapy compared to fibrate monotherapy in patients with dyslipidemia: A meta-analysis
Author(s)
최혜덕신완균[신완균]이주연[이주연]강병철[강병철]
Keywords
TYPE-2 DIABETES-MELLITUS; COMBINED HYPERLIPIDEMIA; FENOFIBRATE THERAPY; MIXED DYSLIPIDEMIA; CLINICAL-TRIALS; SIMVASTATIN; RHABDOMYOLYSIS; ATORVASTATIN; FLUVASTATIN; BEZAFIBRATE
Issue Date
201502
Publisher
ELSEVIER SCIENCE INC
Citation
VASCULAR PHARMACOLOGY, v.65-66, pp.23 - 30
Abstract
Background: Dyslipidemia is a major risk factor for the development of cardiovascular disease. Treatment with fibrate, statins, or other lipid-lowering drugs prevents primary or recurrent cardiovascular events. However, all lipid-lowering drugs have side effects, which may become more severe if combination therapy is prescribed. Methods: We performed a meta-analysis of published data to compare the safety and efficacy of fibrates alone, compared to fibrate-statin combinations, in patients with dyslipidemia. Six articles were assessed in terms of the efficacy of therapy and nine from the viewpoint of therapeutic safety. Results: In terms of efficacy, fibrate-statin combinations afforded significantly greater reductions in the levels of total cholesterol (SE = -2.248; 95% CI 1.986-2.510), LDL cholesterol (SE = -2.274; 95% Cl 2.015-2.533), and triglycerides (SE = -0.465; 95% CI 0.272-0.658) compared to fibrate alone. In terms of safety, treatment with fibrate alone was associated with a significant decrease in the number of kidney-related adverse events (RR = -0.547; 95% CI 0.368-0.812), compared to treatment with fibrate-statin combinations. Conclusion: We suggest that treatment with a fibrate-statin combination affords clinical benefits that are superior to treatment with fibrate alone, but increases the risk of side effects (particularly renal). Therapy should thus be carefully monitored. (C) 2014 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33420http://dx.doi.org/10.1016/j.vph.2014.11.002
ISSN
1537-1891
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약학대학 > 약학부 > Articles
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