Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery

Title
Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery
Author(s)
김종오티르거네쉬라마사미트란탄힙최주연김정환조혁준최한곤[최한곤]용철순
Keywords
POLYELECTROLYTE MULTILAYER FILMS; HYALURONIC-ACID; CHITOSAN; DOXORUBICIN; ALGINATE; CANCER; CYTOTOXICITY; RELEASE; SURFACE; CORE
Issue Date
201402
Publisher
ELSEVIER SCI LTD
Citation
CARBOHYDRATE POLYMERS, v.102, pp.653 - 661
Abstract
Polyelectrolyte multilayers created via sequential adsorption of complimentary materials may be useful in the delivery of small molecules such as anti-cancer drugs. In this study, layer-by-layer (LbL) nanoarchitectures were prepared by step-wise deposition of naturally derived chitosan and hyaluronic acid on negatively charged hybrid solid lipid nanoparticles (SLNs). A doxorubicin/dextran sulfate complex was incorporated into the SLNs. This resulted in the production of spherical nanoparticles similar to 265 nm in diameter, with a zeta potential of approximately -12 mV. The nanoparticles were physically stable and exhibited controlled doxorubicin (DOX) release kinetics. Further pharmacokinetic manipulations revealed that in comparison with both free DOX and uncoated DOX-loaded SLNs, LbL-functionalized SLNs remarkably enhanced the circulation half-life and decreased the elimination rate of the drug. Cumulatively, our results suggest that this novel LbL-coated system, with a pH-responsive shell and molecularly targeted entities, has the potential to act as a vehicle to deliver medication to targeted tumor regions. (C) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33342http://dx.doi.org/10.1016/j.carbpol.2013.11.009
ISSN
0144-8617
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약학대학 > 약학부 > Articles
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