Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

Title
Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants
Author(s)
용철순티아가라쟌렌가르잔유봉규[유봉규]
Keywords
DRUG-DELIVERY; IN-VITRO; ANDROGENETIC ALOPECIA; LIPID NANOPARTICLES; SKIN; PERMEATION; BIOAVAILABILITY; PERMEABILITY; DISPERSIONS; PENETRATION
Issue Date
201402
Publisher
SPRINGER
Citation
AAPS PHARMSCITECH, v.15, no.1, pp.44 - 51
Abstract
The aim of this study was to investigate the capability of two surfactants, Cremophor RH 40 (RH) and Cremophor EL (EL), to prepare liquid crystalline nanoparticles (LCN) and to study its influence on the topical delivery of finasteride (FNS). FNS-loaded LCN was formulated with the two surfactants and characterized for size distribution, morphology, entrapment efficiency, in vitro drug release, and skin permeation/retention. Influence of FNS-loaded LCN on the conformational changes on porcine skin was also studied using attenuated total reflectance Fourier-transform infrared spectroscopy. Transmission electron microscopical image confirmed the formation of LCN. The average particle size of formulations was in the range of 165.1-208.6 and 153.7-243.0 nm, respectively. The formulations prepared with higher surfactant concentrations showed faster release and significantly increased skin permeation. Specifically, LCN prepared with RH 2.5% presented higher permeation flux (0.100+/-0.005 mu gcm(-2)h(-1)) compared with lower concentration (0.029+/-0.007 mu gcm(-2)h(-1)). Typical spectral bands of lipid matrix of porcine skin were shifted to higher wavenumber, indicating increased degree of disorder of the lipid acyl chains which might cause fluidity increase of stratum corneum. Taken together, Cremophor surfactants exhibited a promising potential to stabilize the LCN and significantly augmented the skin permeation of FNS.
URI
http://hdl.handle.net/YU.REPOSITORY/33338http://dx.doi.org/10.1208/s12249-013-0034-2
ISSN
1530-9932
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약학대학 > 약학부 > Articles
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