Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)

Title
Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)
Author(s)
김종오이동원마라시니니르말포우델비자이김정환조혁준문보경최한곤[최한곤]용철순
Keywords
ENHANCED ORAL BIOAVAILABILITY; RESPONSE-SURFACE METHODOLOGY; LIPID-BASED FORMULATIONS; SPRAY-DRYING TECHNIQUE; LIPOPHILIC DRUGS; INTESTINAL-ABSORPTION; STATISTICAL DESIGN; DISSOLUTION; EMULSIFICATION; CLASSIFICATION
Issue Date
201402
Publisher
INFORMA HEALTHCARE
Citation
JOURNAL OF MICROENCAPSULATION, v.31, no.1, pp.31 - 40
Abstract
This study was designed to optimize a fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS) by using a response surface methodology. Box-Behnken design (BBD) and its desirability function were used to optimize the SMEDDS. The independent factors were the amounts of Labrafil M 1944 CS, Labrasol, and Capryol PGMC and the dependent variables were droplet size, cumulative percentage of drug released in 30 min and equilibrium solubility of fenofibrate in SMEDDS. Various response surface graphs were used to understand the effects of each factor, and the desirability function was then adjusted to optimize SMEDDS formulation. The experimental values of optimized formulation were in close agreement with predicted values. Furthermore, in vivo pharmacokinetic study of the optimized formulation showed significant increase in relative oral bioavailability compared to that of the powder suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SMEDDS formulation and in identifying the effects of formulation variables.
URI
http://hdl.handle.net/YU.REPOSITORY/33334http://dx.doi.org/10.3109/02652048.2013.805837
ISSN
0265-2048
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약학대학 > 약학부 > Articles
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