Fabrication of poly(ethylene oxide) hydrogels for wound dressing application using E-beam

Title
Fabrication of poly(ethylene oxide) hydrogels for wound dressing application using E-beam
Author(s)
김성철김정환김종오하리안토구세광[구세광]조현국한도흥허필호[허필호]
Keywords
IN-VIVO EVALUATION; HEALING EVALUATION; GEL CHARACTERIZATION; POLYVINYL-ALCOHOL; IRRADIATION; RADIATION; CHITOSAN; MODEL; FILMS
Issue Date
201402
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v.22, no.2, pp.131 - 138
Abstract
Cross-linked poly(ethylene oxide) (PEO) hydrogel was developed for application to wound dressings. To determine the optimum conditions for wound dressing materials, PEO with different molecular weights and various PEO/poly(ethylene glycol) diacrylate (PEGDA) compositions were irradiated in order to obtain cross-linked hydrogels using an electron beam with various beam intensities. The contents of the PEGDA influenced the gel fraction, swelling ratio, mechanical properties, and water vapor transmission rate. To evaluate the healing effect of PEO/ PEGDA cross-linked hydrogel for wound dressing, wounds on the backs of mice were covered with PEO/PEGDA hydrogel films. Healing under the wet environment of the hydrogel dressing was faster than with a gauze control and a commercial reference. The results demonstrate the possibility of the facile production of mechanically robust and transparent wound dressing materials with improved wound healing characteristics.
URI
http://hdl.handle.net/YU.REPOSITORY/33292http://dx.doi.org/10.1007/s13233-014-2023-z
ISSN
1598-5032
Appears in Collections:
공과대학 > 화학공학부 > Articles
약학대학 > 약학부 > Articles
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