Pregnancy Loss Following Coxsackievirus B3 Infection in Mice during Early Gestation Due to High Expression of Coxsackievirus-Adenovirus Receptor (CAR) in Uterus and Embryo

Title
Pregnancy Loss Following Coxsackievirus B3 Infection in Mice during Early Gestation Due to High Expression of Coxsackievirus-Adenovirus Receptor (CAR) in Uterus and Embryo
Author(s)
박호선황지영이경민김윤화심혜민배영경황정혜[황정혜]
Keywords
TRANSPLACENTAL INFECTION; TIGHT JUNCTION; VIRUSES; CELLS; PLACENTA; MOUSE; TRANSMISSION; HEPATITIS; GROWTH; BRAIN
Issue Date
201402
Publisher
INT PRESS EDITING CENTRE INC
Citation
EXPERIMENTAL ANIMALS, v.63, no.1, pp.63 - 72
Abstract
Coxsackieviruses are important pathogens in children and the outcomes of neonatal infection can be serious or fatal. However, the outcomes of coxsackievirus infection during early gestation are not well defined. In this study, we examined the possibility of vertical transmission of coxsackievirus B3 (CVB3) and the effects of CVB3 infection on early pregnancy of ICR mice. We found that the coxsackievirus and adenovirus receptor (CAR) was highly expressed not only in embryos but also in the uterus of ICR mice. CVB3 replicated in the uterus 1 to 7 days post-infection (dpi), with the highest titer at 3 dpi. The pregnancy loss rate in mice infected with CVB3 during early gestation was 38.3%, compared to 4.7% and 2.7% in mock-infected and UV-inactivated-CVB3 infected pregnant mice, respectively. These data suggest that the uterus and embryo, which express abundant CAR, are important targets of CVB3 and that the vertical transmission of CVB3 during early gestation induces pregnancy loss.
URI
http://hdl.handle.net/YU.REPOSITORY/33257
ISSN
1341-1357
Appears in Collections:
의과대학 > 미생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 병리학교실 > Articles
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