alpha-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides

Title
alpha-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides
Author(s)
비벡바지파이박용하MinKyun Na[MinKyun Na]강선철[강선철]
Keywords
MIKI EX HU; SKIN; LEAVES
Issue Date
201503
Publisher
BIOMED CENTRAL LTD
Citation
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.15
Abstract
Background: Nowadays plant derived natural compounds have gained huge amount of research attention especially in food and medicine industries due to their multitude of biological and therapeutic properties as alternative medicines. Methods: In this study, a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides was evaluated for its alpha-glucosidase and tyrosinase inhibitory efficacy in terms of its potent anti-diabetic and depigmentation potential, respectively. Results: As a result, taxoquinone at the concentration range of 100-3,000 mu g/mL and 200-1,000 mu g/mL showed potent efficacy on inhibiting a-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively. Conclusions: The findings of this study clearly evident potent therapeutic efficacy of an abietane diterpenoid taxoquinone isolated from M. glyptostroboides with a possibility for using it as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent.
URI
http://hdl.handle.net/YU.REPOSITORY/33251http://dx.doi.org/10.1186/s12906-015-0626-3
ISSN
1472-6882
Appears in Collections:
중앙도서관 > rims journal
생명공학부 > 생명공학부 > Articles
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