Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients

Title
Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients
Author(s)
이재민박미림[박미림]이영호[이영호]이수현[이수현]유건희[유건희]구홍회[구홍회]성기웅[성기웅]이지원[이지원]하정옥강형진[강형진]박경덕[박경덕]신희영[신희영]안효섭[안효섭]
Keywords
STEM-CELL TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; CMV INFECTION; DISEASE; RISK; SEROSTATUS; REACTIVATION; EXPERIENCE; FOSCARNET; IMPACT
Issue Date
201503
Publisher
SPRINGER
Citation
ANNALS OF HEMATOLOGY, v.94, no.3, pp.481 - 489
Abstract
To gain insight into the natural history of cytomegalovirus (CMV) infection following unrelated cord blood transplantation (UCBT) in seropositive patients, we analyzed the data of 349 seropositive patients who received UCBT in Korea between 2000 and 2011. CMV reactivation occurred in 49 % (171/349) of the CMV-seropositive transplant recipients at a median of 31 days post UCBT. One hundred sixty-four out of 171 patients (96 %) received preemptive therapy. The median duration of CMV reactivation was 29 days. In multivariate analysis, weight > 22 kg, use of total body irradiation, use of pre-transplant antithymocyte globulin, graft-versus-host disease (GVHD) prophylaxis with mycophenolate mofetil, and presence of grade II-IV acute GVHD were independent predictors of CMV reactivation. CMV reactivation did not impact transplantation-related mortality (TRM), leukemia relapse, or survival. CMV disease was diagnosed in 62 patients (17.8 %) at a median 55 days after UCBT. Longer duration of CMV reactivation was the only risk factor for progression to CMV disease (p = 0.01). CMV disease resulted in higher TRM (56.0 vs. 31.4 %, p < 0.01) and lower survival (36.1 vs. 55.1 %, p = 0.02).
URI
http://hdl.handle.net/YU.REPOSITORY/33247http://dx.doi.org/10.1007/s00277-014-2222-x
ISSN
0939-5555
Appears in Collections:
의과대학 > 소아청소년과학교실 > Articles
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