The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study

Title
The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study
Author(s)
장성호권혁규
Keywords
MINIMALLY CONSCIOUS STATE; VEGETATIVE STATE; AROUSAL SYSTEM; CONNECTIVITY; TRACTOGRAPHY; INJURY; COMA; SPECTROSCOPY; RECOVERY; THALAMUS
Issue Date
201503
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.590, pp.58 - 61
Abstract
The ascending reticular activating system (ARAS) is responsible for regulation of consciousness. Precise evaluation of the ARAS is important for diagnosis and management of patients with impaired consciousness. In the current study, we attempted to reconstruct the portion of the ARAS from the pontine reticular formation (RF) to the hypothalamus in normal subjects, using diffusion tensor imaging (DTI). A total of 31 healthy subjects were recruited for this study. DTI scanning was performed using 1.5-T, and the ARAS from the pontine RF to the hypothalamus was reconstructed. Values of fractional anisotropy, mean diffusivity, and tract volume of the ARAS from the pontine RF to the hypothalamus were measured. In all subjects, the ARAS from the pontine RF to the hypothalamus originated from the RF at the level of the mid-pons, where the trigeminal nerve could be seen, ascended through the periaqueductal gray matter of the midbrain anterolaterally to the anterior commissure level, and then terminated into the hypothalamus. No significant differences in DTI parameters were observed between the left and right hemispheres and between males and females (p < 0.05). We identified the ARAS between the pontine RF and the hypothalamus in normal subjects using DTI. We believe that the reconstruction methodology and the results of this study would be useful to clinicians involved in the care of patients with impaired consciousness and researchers in studies of the ARAS. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33246http://dx.doi.org/10.1016/j.neulet.2015.01.071
ISSN
0304-3940
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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