Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir

Title
Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir
Author(s)
용철순트란탄힙티르거네쉬라마사미포우델비자이마라시니니르말문보경조혁준최한곤[최한곤]김종오
Keywords
IN-VITRO RELEASE; CHITOSAN MICROSPHERES; CROSS-LINKING; SWELLING BEHAVIOR; DRUG-DELIVERY; FORMULATION; NANOPARTICLES; OPTIMIZATION; EFFICACY; GENIPIN
Issue Date
201402
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v.22, no.2, pp.124 - 130
Abstract
The aim of this study was to prepare ganciclovir (GCV)-loaded cross-linked gelatin microspheres by spray-drying method. The microspheres were characterized in terms of particle size, surface morphology, loading efficiency, thermal behavior, physical characteristics, swelling properties, and the release profile in vitro. The major process and formulation parameters were optimized to obtain smaller particles with high loading capacity. The physical state examination confirmed the molecular-level dispersion of drug in the polymer. The loading efficiency determined by high-performance liquid chromatography (HPLC) was around 68%. The in vitro release experiments revealed that the GCV released from the gelatin microspheres was related to the extent of swelling, which was proportional to the drug-to-polymer ratio. These results suggest that cross-linked gelatin microspheres could be a suitable drug-delivery system for GCV.
URI
http://hdl.handle.net/YU.REPOSITORY/33229http://dx.doi.org/10.1007/s13233-014-2018-9
ISSN
1598-5032
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약학대학 > 약학부 > Articles
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