Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp F9A015

Title
Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp F9A015
Author(s)
최혁재김희영[김희영]양인호[양인호]유신용[유신용]원동환[원동환]Awadut G. Giri[Awadut G. Giri]왕위홍[왕위홍]진정욱[진정욱]한동엽[한동엽]김은희[김은희]한철경[한철경]이지혜[이지혜]남상집[남상집]호원경[호원경]강헌중[강헌중]
Keywords
INSULIN-SECRETION; GLUCOSE; KV2.1; DRUGS
Issue Date
201503
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.78, no.3, pp.363 - 367
Abstract
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 mu M, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/33215http://dx.doi.org/10.1021/np5007586
ISSN
0163-3864
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약학대학 > 약학부 > Articles
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