An advanced and novel one-pot synthetic method for diverse benzo[c]chromen-6-ones by transition-metal free mild base-promoted domino reactions of substituted 2-hydroxychalcones with beta-ketoesters and its application to polysubstituted terphenyls

Title
An advanced and novel one-pot synthetic method for diverse benzo[c]chromen-6-ones by transition-metal free mild base-promoted domino reactions of substituted 2-hydroxychalcones with beta-ketoesters and its application to polysubstituted terphenyls
Author(s)
이용록테즈나라얀포우델
Keywords
CROSS-COUPLING REACTIONS; ENDOPHYTIC FUNGUS; LACTONIZATION SEQUENCE; SECONDARY METABOLITES; DEFUCOGILVOCARCIN-V; BIOLOGICAL-ACTIVITY; LICHEN MYCOBIONTS; RECEPTOR AGONISTS; GILVOCARCIN-V; DERIVATIVES
Issue Date
201402
Publisher
ROYAL SOC CHEMISTRY
Citation
ORGANIC & BIOMOLECULAR CHEMISTRY, v.12, no.6, pp.919 - 930
Abstract
Novel and efficient one-pot syntheses of a variety of benzo[c]chromen-6-one derivatives were accomplished using Cs2CO3-promoted reactions between substituted 2-hydroxychalcones and beta-ketoesters. These reactions involved domino Michael addition/intramolecular aldol/oxidative aromatization/lactonization and provided a rapid synthetic route for the production of biologically interesting novel benzo[c]chromen-6-one molecules bearing several different substituents on benzene rings. As an application of this methodology, several synthesized benzo[c]chromen-6-ones were transformed into highly functionalized novel terphenyls.
URI
http://hdl.handle.net/YU.REPOSITORY/33181http://dx.doi.org/10.1039/c3ob41800f
ISSN
1477-0520
Appears in Collections:
공과대학 > 화학공학부 > Articles
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