Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities

Title
Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities
Author(s)
이용록아크베르이드하야둘라하립개김성홍[김성홍]위영중이종순
Keywords
ONE-POT SYNTHESIS; RUBIA-CORDIFOLIA; NATURAL-PRODUCTS; EFFICIENT SYNTHESIS; ANTHRAQUINONES; CONSTITUENTS; TRANS-3,4-DIHYDROXY-3,4-DIHYDROMOLLUGIN; NAPHTHOQUINONES; TINCTORUM; ROOTS
Issue Date
201402
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOORGANIC CHEMISTRY, v.52, pp.77 - 82
Abstract
Novel and diverse mollugin analogues (1-12) were synthesized using PhB(OH)(2)/AcOH-mediated electrocyclization reaction as a key step. The newly synthesized compounds were screened for antioxidant and antibacterial activities. Compounds 1, 2, 5, 6, 8, and 10-12 showed high antioxidant activities in DPPH inhibition (IC50 = 0.52-1.11 mu M) compared with BHT (IC50 = 9.67 mu M). Compounds 3 exhibited potent antibacterial activity against Staphylococcus aureus (KCTC-1916) bacterial strain at 100 mu g/mL. Structures of newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR data and high-resolution mass spectrometry. (C) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33175http://dx.doi.org/10.1016/j.bioorg.2013.11.008
ISSN
0045-2068
Appears in Collections:
공과대학 > 화학공학부 > Articles
자연자원대학 > 식품공학과 > Articles
이과대학 > 화학생화학부 > Articles
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