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dc.contributor.author용철순ko
dc.contributor.author엄의동ko
dc.contributor.author김동욱[김동욱]ko
dc.contributor.author김종오ko
dc.contributor.author최한곤[최한곤]ko
dc.contributor.author오동훈ko
dc.date.accessioned2015-12-17T05:00:12Z-
dc.date.available2015-12-17T05:00:12Z-
dc.date.created2015-11-13-
dc.date.issued201402-
dc.identifier.citationDRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.40, no.2, pp.172 - 177-
dc.identifier.issn0363-9045-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/33165-
dc.identifier.urihttp://dx.doi.org/10.3109/03639045.2012.752501-
dc.description.abstractObjective: A novel flurbiprofen-loaded nanoemulsion which gave uniform emulsion droplets with a narrow size distribution was previously reported to be prepared using membrane emulsification method. The purpose of this study is to develop a novel flurbiprofen-loaded nanoparticle with a narrow size distribution and improved bioavailability. Method: The nanoparticle was prepared by solidifying nanoemulsion using sucrose as a carrier via spray drying method. Its physicochemical properties were investigated using SEM, DSC and PXRD. Furthermore, dissolution and bioavailability in rats were evaluated compared to a flurbiprofen-loaded commercial product. Results: The flurbiprofen-loaded nanoparticles with flurbiprofen/sucrose/surfactant mixture (1/20/2, weight ratio) gave good solidification and no stickiness. They associated with about 70000-fold improved drug solubility and had a mean size of about 300 nm with a narrow size distribution. Flurbiprofen was present in a changed amorphous state in these nanoparticles. Moreover, the nanoparticles gave significantly shorter T-max, and higher AUC and C-max of the drug compared to the commercial product (p<0.05). In particular, they showed about ninefold higher AUC of the drug than did the commercial product Conclusion: These flurbiprofen-loaded nanoparticles prepared with sucrose by the membrane emulsification and spray drying method would be a potential candidate for orally delivering poorly water-soluble flurbiprofen with enhanced bioavailability.-
dc.language영어-
dc.publisherINFORMA HEALTHCARE-
dc.subjectSPRAY-DRYING TECHNIQUE-
dc.subjectSOLID-DISPERSION-
dc.subjectPHYSICOCHEMICAL CHARACTERIZATION-
dc.subjectBIOAVAILABILITY-
dc.subjectSOLUBILITY-
dc.subjectGELATIN-
dc.subjectPHARMACOKINETICS-
dc.subjectEMULSIFICATION-
dc.subjectDELIVERY-
dc.titleDevelopment of flurbiprofen-loaded nanoparticles with a narrow size distribution using sucrose-
dc.typeArticle-
dc.identifier.wosid000331258400004-
dc.identifier.scopusid2-s2.0-84893328339-
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