Development of flurbiprofen-loaded nanoparticles with a narrow size distribution using sucrose

Title
Development of flurbiprofen-loaded nanoparticles with a narrow size distribution using sucrose
Author(s)
용철순엄의동김동욱[김동욱]김종오최한곤[최한곤]오동훈
Keywords
SPRAY-DRYING TECHNIQUE; SOLID-DISPERSION; PHYSICOCHEMICAL CHARACTERIZATION; BIOAVAILABILITY; SOLUBILITY; GELATIN; PHARMACOKINETICS; EMULSIFICATION; DELIVERY
Issue Date
201402
Publisher
INFORMA HEALTHCARE
Citation
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.40, no.2, pp.172 - 177
Abstract
Objective: A novel flurbiprofen-loaded nanoemulsion which gave uniform emulsion droplets with a narrow size distribution was previously reported to be prepared using membrane emulsification method. The purpose of this study is to develop a novel flurbiprofen-loaded nanoparticle with a narrow size distribution and improved bioavailability. Method: The nanoparticle was prepared by solidifying nanoemulsion using sucrose as a carrier via spray drying method. Its physicochemical properties were investigated using SEM, DSC and PXRD. Furthermore, dissolution and bioavailability in rats were evaluated compared to a flurbiprofen-loaded commercial product. Results: The flurbiprofen-loaded nanoparticles with flurbiprofen/sucrose/surfactant mixture (1/20/2, weight ratio) gave good solidification and no stickiness. They associated with about 70000-fold improved drug solubility and had a mean size of about 300 nm with a narrow size distribution. Flurbiprofen was present in a changed amorphous state in these nanoparticles. Moreover, the nanoparticles gave significantly shorter T-max, and higher AUC and C-max of the drug compared to the commercial product (p<0.05). In particular, they showed about ninefold higher AUC of the drug than did the commercial product Conclusion: These flurbiprofen-loaded nanoparticles prepared with sucrose by the membrane emulsification and spray drying method would be a potential candidate for orally delivering poorly water-soluble flurbiprofen with enhanced bioavailability.
URI
http://hdl.handle.net/YU.REPOSITORY/33165http://dx.doi.org/10.3109/03639045.2012.752501
ISSN
0363-9045
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약학대학 > 약학부 > Articles
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