Bromopropane compounds inhibit osteogenesis by ERK-dependent Runx2 inhibition in C2C12 cells

Title
Bromopropane compounds inhibit osteogenesis by ERK-dependent Runx2 inhibition in C2C12 cells
Author(s)
정태천정형민[정형민]최유희[최유희]정혜광[정혜광]이광열[이광열]
Keywords
PARATHYROID-HORMONE REGULATION; SIGNAL-REGULATED KINASE; NF-KAPPA-B; OSTEOBLAST DIFFERENTIATION; PHOSPHATIDYLINOSITOL 3-KINASE; IN-VITRO; 2-BROMOPROPANE; 1-BROMOPROPANE; ACTIVATION; RAT
Issue Date
201402
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.2, pp.276 - 283
Abstract
Bromopropane (BP) is a halogenated alkan compound used in various industries as chemical intermediates, extraction solvents, and degreasing compounds. Halogenated alkan compounds can damage the nervous system, immune system, and hematopoietic and reproductive functions in animals and humans. However, the effect of BPs on bone formation has not yet been examined. This study examined the effects of BPs on osteoblast differentiation and analyzed the mechanisms involved in C2C12, mesenchymal stem cells. BPs dose dependently reduced the alkaline phosphatase activity, expression levels and promoter activity of bone marker genes. Additionally, 1,2-dibromopropane (1,2-DBP) significantly reduced the levels and transcriptional activity of Runx2 and Osterix, major bone transcription factors, in BMP2 induced C2C12 cells. Furthermore, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) were significantly inhibited by 1,2-DBP. These results demonstrate that BPs inhibit osteoblast differentiation by suppressing Runx2 and Osterix through the ERK/JNK pathway.
URI
http://hdl.handle.net/YU.REPOSITORY/33153http://dx.doi.org/10.1007/s12272-013-0178-3
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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