Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation

Title
Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation
Author(s)
박필훈김희훈[김희훈]박승빈[박승빈]이소영[이소영]권택규[권택규]신태용[신태용]이승호김상현[김상현]
Keywords
FACTOR-KAPPA-B; GENE-EXPRESSION; PROTEIN-KINASE; MONOMERIC IGE; CALCIUM; HISTAMINE; MODEL; NFAT; DEGRANULATION; CALCINEURIN
Issue Date
201402
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
TOXICOLOGY AND APPLIED PHARMACOLOGY, v.274, no.3, pp.455 - 461
Abstract
A great number of people are suffering from allergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in human health. Putranjivain A (PJA), member of ellagitannin, is known to possess beneficial effects including anticancer and anti-viral activities. The aim of the present study was to elucidate whether PJA modulates the allergic inflammatory reaction and to study its possible mechanisms of action using mast cell-based in vitro and in vivo models. The study was performed in anaphylaxis mouse model and cultured mast cells. PJA inhibited the expression of pro-inflammatory cytokines in immunoglobulin E-stimulated mast cells. PJA reduced this expression by inhibiting nuclear factor (NF)-kappa B and nuclear factor of activated T cell. The oral administration of PJA reduced systemic and cutaneous anaphylaxis, the release of serum histamine, and the expression of the histamine H-1 receptor. In addition, PJA attenuated the activation of mast cells. PJA inhibited the release of histamine from various types of mast cells by the suppression of intracellular calcium. The inhibitory activity of PJA on the allergic reaction was similar to that of disodium cromoglycate, a known anti-allergic drug. These results suggest that PJA can facilitate the prevention or treatment of allergic inflammatory diseases mediated by mast cells. (C) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33151http://dx.doi.org/10.1016/j.taap.2013.12.006
ISSN
0041-008X
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약학대학 > 약학부 > Articles
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