Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.

Title
Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.
Author(s)
최혁재Weihong Wang[Weihong Wang]이태구[이태구]Rahul S. Patil[Rahul S. Patil]문보라[문보라]양인호[양인호]김희영[김희영]한동엽[한동엽]원동환[원동환]이지혜[이지혜]이예희[이예희]남상집[남상집]강헌중[강헌중]
Keywords
ABSOLUTE-CONFIGURATIONS; IL-6 PRODUCTION; SOFT CORAL; STEROIDS
Issue Date
201503
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.78, no.3, pp.368 - 373
Abstract
Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 1-3 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-alpha, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.
URI
http://hdl.handle.net/YU.REPOSITORY/33130http://dx.doi.org/10.1021/np500760v
ISSN
0163-3864
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE