HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells

Title
HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells
Author(s)
정태천김진아[김진아]김동환[김동환]Hossain MA[Hossain MA]김민영[김민영]성보경[성보경]윤정현[윤정현]서홍석[서홍석]정해영[정해영]김남득[김남득]
Keywords
IN-VIVO; P53; STATISTICS; ACTIVATION; EXPRESSION; MECHANISM; PATHWAYS; KINASES; COMPLEX; PROTEIN
Issue Date
201402
Publisher
SPANDIDOS PUBL LTD
Citation
INTERNATIONAL JOURNAL OF ONCOLOGY, v.44, no.2, pp.473 - 480
Abstract
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21(WAF1/CIP1)-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
URI
http://hdl.handle.net/YU.REPOSITORY/33123http://dx.doi.org/10.3892/ijo.2013.2207
ISSN
1019-6439
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약학대학 > 약학부 > Articles
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