Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities

Title
Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities
Author(s)
이위Zhou Wei[Zhou Wei]김은지[김은지]심상희강희경[강희경]김영호[김영호]
Keywords
HERICIUM-ERINACEUM; C-MYC; CANCER CELLS; APOPTOSIS; OVEREXPRESSION; GROWTH; AKT
Issue Date
201503
Publisher
ELSEVIER SCI LTD
Citation
FOOD CHEMISTRY, v.170, pp.336 - 342
Abstract
Lion's Mane Mushroom (Hericium erinaceum) is a traditional edible mushroom widely used in culinary applications and as an herbal medicine in East Asian countries. In the present study, two new aromatic compounds, hericerin A (1) and isohericenone J (5), along with five known compounds, isoericerin (2), hericerin (3), N-De phenylethyl isohericerin (4), hericenone J (6), and 4-[3',7'-dimethyl-2',6'-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol (7), were isolated from a methanol extract of the fruiting bodies of H. erinaceum. The chemical structures of the compounds were determined from mass spectra and 1D- and 2D NMR spectroscopy. The anticancer effects of the isolated compounds were examined in HL-60 human acute promyelocytic leukaemia cells. Hericerin A (1) and hericerin (3) significantly reduced cell proliferation with IC50 values of 3.06 and 5.47 mu M, respectively. These same compounds also induced apoptosis of HL-60 cells, accompanied by time-dependent down-regulation of p-AKT and c-myc levels. These data suggest that compounds 1 and 3 from H. erinaceum are suitable for use in potential cancer treatments. (C) 2014 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33090http://dx.doi.org/10.1016/j.foodchem.2014.08.078
ISSN
0308-8146
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생명공학부 > 생명공학부 > Articles
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