Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis

Title
Salvia plebeia extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis
Author(s)
박필훈김상현[김상현]최진경[최진경]오현미[오현미]박지훈[박지훈]최정호[최정호]사금희[사금희]강영모[강영모]신태용[신태용]노명철[노명철]
Keywords
COLLAGEN-INDUCED ARTHRITIS; NF-KAPPA-B; JOINT DESTRUCTION; PATHOGENESIS; SYNOVIOCYTES; MECHANISMS; CYTOKINES; PEPTIDE; PATHWAY; DISEASE
Issue Date
201503
Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
Citation
PHYTOMEDICINE, v.22, no.3, pp.415 - 422
Abstract
Salvia plebeia R. Br. has been used to treat a variety of inflammatory diseases and as an antioxidant in many countries, including Korea and China. In this study, we investigated the effects of S. plebeia extract (WE) on inflammatory arthritis and the underlying mechanisms of action. We used a collagen-induced arthritis (CIA) mouse model. TNF-alpha-stimulated rheumatoid arthritis (RA) synovial fibroblasts were used to elucidate the underlying mechanisms of action. Oral administration of SPE improved the clinical arthritis score, footpad thickness, and histologic changes, as well as serum IgG1 and IgG2a levels. SPE administration inhibited Th1/Th2/Th17 phenotype CD4(+) T lymphocyte expansion in inguinal lymph node and expression of inflammatory mediators such as cytokines, MMP-1, and MMP-3 in the ankle joint tissue. SPE significantly suppressed the expression of cytokines and MMP-1 by down-regulating NF-kappa B, Akt, and mitogen-activated protein kinases in RA synovial fibroblasts. Taken together, these results indicate that SPE is therapeutically efficacious against chronic inflammatory arthritis, suggesting that SPE is a candidate for treating RA. (C) 2015 Elsevier GmbH. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/33050http://dx.doi.org/10.1016/j.physmed.2015.01.007
ISSN
0944-7113
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약학대학 > 약학부 > Articles
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