Addition of Anti-neu Antibody to Local Irradiation Can Improve Tumor-Bearing BALB/c Mouse Survival through Immune-Mediated Mechanisms

Title
Addition of Anti-neu Antibody to Local Irradiation Can Improve Tumor-Bearing BALB/c Mouse Survival through Immune-Mediated Mechanisms
Author(s)
곽민정마선영[마선영]송현근[송현근]박진희[박진희]강미선[강미선]최재혁[최재혁]김진호[김진호]김기향[김기향]박성재[박성재]박동현[박동현]
Keywords
BREAST-CANCER CELLS; INTRATUMORAL HETEROGENEITY; MONOCLONAL-ANTIBODY; T-CELLS; RADIATION; RADIOTHERAPY; THERAPY; TRASTUZUMAB; RECEPTOR; IMMUNOTHERAPY
Issue Date
201503
Publisher
RADIATION RESEARCH SOC
Citation
RADIATION RESEARCH, v.183, no.3, pp.271 - 278
Abstract
This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a nonmetastatic neu-positive tumor and a metastatic neu-negative tumor. While local irradiation alone could control the primary tumor in a dose-dependent manner, it did not improve mouse survival. Combined treatment comprised of local irradiation and anti-neu antibody of tumor-bearing BALB/c mice significantly improved mouse survival (P < 0.5), even though the tumor growth was similar to that of the irradiated-alone group. The combined treatment significantly reduced metastatic tumor masses in the lung and increased immune cell infiltration in primary tumor tissues. However, immune deficient nude mice with tumors did not exhibit prolonged survival in response to the combined treatment. Collectively, these results show that combined local irradiation and anti-neu antibody can elicit an immune-mediated abscopal effect to extend survival. Although the mechanism for abscopal effects induced by the combined treatment of radiation and anti-HER2/neu antibody was not elucidated, to our knowledge this is the first published study to describe the abscopal effect induced by the combination of local irradiation and the anti-HER2/neu antibody. (C) 2015 by Radiation Research Society
URI
http://hdl.handle.net/YU.REPOSITORY/33030http://dx.doi.org/10.1667/RR13800.1
ISSN
0033-7587
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이과대학 > 통계학과 > Articles
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